Quantitative Trait Loci Specifying the Response of Body Temperature to Dietary Restriction

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Quantitative trait Loci specifying the response of body temperature to dietary restriction.

Dietary restriction (DR) retards aging and mortality across a variety of taxa. In homeotherms, one of the hallmarks of DR is lower mean body temperature (T(b)), which might be directly responsible for some aspects of DR-mediated life extension. We conducted a quantitative trait locus (QTL) analysis of the response of T(b) to DR in mice using a panel of 22 LSXSS recombinant inbred strains, teste...

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Dietary restriction (DR, also referred to as calorie restriction, energy restriction, and food restriction) retards senescence and increases longevity in mammals. DR also lowers mean body temperature (T(b)), and thus mean T(b) might be useful as a covariate of DR-induced life extension. Indeed, lower T(b) could itself underlie some of the beneficial life-extension effects that occur during DR. ...

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ژورنال

عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

سال: 2004

ISSN: 1079-5006,1758-535X

DOI: 10.1093/gerona/59.2.b118